The development of the quinoa cultivation has become more and more important (Quenopodium quinoa Willd) in the Cundiboyacense plateau, because of its important nutritional, gastronomic and productive value; as well as its easy adaptability to the edaphic and climatic conditions, that allows the quinoa to become a potential alternative in the agricultural sector. The aim of the research was to evaluate the agronomic response of the quinoa in the application of organic-mineral fertilizers, chemical and chemical mixture plus organic-mineral mixture at the time of planting and 54 days long after planting in the municipality of Ventaquemada – Boyacá. For this, a study was carried out in Victoria Granja Agroecológica, where was planted seeds of quinoa variedad dulce from Soracá; a completely random statistical design with three treatments and absolute control. The results were exposed to analysis of variance and the Tukey comparison test. There were significant differences in all the variables evaluated, where T3 revealed the best results for dry and fresh weight of panoja, dry weight of plants and seed yield in comparison to T1. Therefore, the use and application of organic-mineral manures, becomes in an important option for fertilizer, which favors the performance and rentability of quinoa crop under the Cundiboyacense plateau conditions.