<p>The importance of calcium in many metabolic processes is well known, and its important relationship to health and low survival rates have been reported. In Colombia, secondary nutritional hyperparathyroidism due to calcium deficiencies is reported and it has been recognized for decades as a pathology with clinical signs that become evident later and may begin with slight signs such as intermittent claudications, but only patients with serious changes are evaluated by demineralization, mainly in the bones of the head. This causes a big impact because of the loss of animals due to muscle-skeletal problems. In addition to this, multiple nutritional and management factors in equine production in the country can affect the absorption and metabolism of calcium, exacerbating the incidence of disease. Although diagnostic tests are performed, they only confirm the advanced condition and no tests have been studied for early diagnosis of resorption, before the lesions progress. The objective is to understand the disease and evaluate the diagnostic possibility of collagen I terminal carboxyl telopeptide (CTX I) during an early stage of the disease, decreasing its athletic and economic impact. A review of printed and electronic sources was carried out, by consulting databases and journals registered in Universities, without date restriction, with descriptors in all languages related to the disease and diagnosis. The options for the use of CTX in the diagnosis of bone resorption problems were evaluated.</p>