<p>The vaccines to prevent coronavirus 2 (SARS-CoV-2), which is responsible for severe acute respiratory syndrome, have emerged as the most promising strategy to contain the pandemic. Therefore, this study is aimed at showing the progress of vaccines distributed, allocated and applied by dose for vaccination against SARS-COV-2 in the territorial entities of Colombia, between February 17 and August 5, 2021. The present study was an analytical cross-sectional study designed specially to collect information on vaccines given in Colombia. As a source of information, the national vaccination plan against COVID-19 was consulted on the website of the Ministry of Health and Social Protection. According to the data, the territorial entities with the highest percentage of doses assigned were: Bogotá (18.61), Antioquia (14.92), Valle del Cauca (8.82), and the territorial entities with the highest percentage of vaccines applied per dose were: Bogotá (18.61), Antioquia (14.92), Valle del Cauca (8.82). On the other hand, the territorial entities with the highest percentage of vaccines applied per dose were: San Andrés and Providencia (87), Valle (56.75), Atlántico (56.75), Caldas (56.72), and Vaupés (56). In conclusion, vaccination is essential during the COVID-19 pandemic to reduce infection rates and deaths.&nbsp; The efficacy of the vaccine is based on the formation of a long-lasting immune response and on the proportion of people who are vaccinated.</p>