This study analyzes the main cultural particularities: worldviews and ways of knowing that are associated with the use and management practices of forest resources in the Colombian Amazon. The theoretical cutting proposal contrasts, cultural level, the forms of appropriation of forest resources in indigenous and urban contexts in light of the importance that such activity involves the establishment of management strategies biodiversity in Colombia. Thus, offers an integrated perspective that will address environmental situations considering conflicting factors not only biological but cultural in various scenarios, to give substance to the decisions made and provide a reasonable treatment that enables the implementation of environmental regulatory mechanisms in strategic special biological areas as the Colombian Amazon. Finally, reflect on the importance of facilitating the functional analysis of the connections and interrelationships of ecosystem components, including human com-munities, to sketch involving both biological and social guidelines for sustainable use of biodiversity.