<p>This article focused on the asymmetric integration factors of free trade agreements such as North American Free Trade Agreement (NAFTA) and the Mesoamerican Plan and their results; the exacerbation of poverty and extreme poverty, as well as the economic and social impacts derived from them in the regions located in Mexico. It examines the capital trajectory and the way in which it disintegrates regions, on the basis of their expansive and intensive nature. It takes as a study case, the state of Puebla and its municipalities, in which are being extinguished their customs, traditions, and languages, spreading market ideology, appropriating the existing natural resources mainly in the places of peasant and indigenous population. The marginalization gaps have been increased in the municipalities of Puebla, therefore the critical and objective perspective is questioning the public policies of the official discourse, which has excluded broad sectors of the population from the development guaranteed by the Free Trade Agreements.</p>