<p>Sir Ronald Fisher (1890-1962) was a genetics professor and many of his statistical innovations were shown in the development of genetic statistic methodology. However, while his mathematical statistic contributions are easily identified, his supremacy in populations' genetics was shared with Sewall Wright (1889 - 1988) and J. S. S. Haldane (1892 -1965). This document shows some of Fisher’s best contributions to the genetic statistic bases and his interactions with Wright and Haldane, whom contributed to the development of the topic. With modern technology, statistical methodology as much as genetic Information is changing. Nevertheless, many Fisher's works remain valid and can still serve as a base for future researches in DNA data statistical. This author's work reflects his vision about the statistic role in the scientific inference expressed in 1949.</p>